Isotopically Labeled Compounds
Medchemexpress LLC Indomethacin-d4 Methyl Ester | 1217064-61-3 | 98.4% | C20H14D4ClNO4 | 1 MG
Indomethacin-d4 Methyl Ester is a deuterium-labeled form of Indomethacin, a potent, blood-brain permeable, and nonselective inhibitor of both COX-1 and COX-2 enzymes. It demonstrates inhibitory activity with IC50s of 18 nM for human COX-1 and 26 nM for COX-2 in CHO cells. This compound has also been observed to disrupt autophagic flux by interfering with the normal function of lysosomes.
- Deuterium labeled derivative of indomethacin
- Potent and nonselective COX-1 and COX-2 inhibitor
- Blood-brain barrier permeable
- Disrupts autophagic flux through lysosomal interference
- Useful as a tracer or internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC D-Glucose-d1-3 | 106032-60-4 | 99.9% | 5 MG
D-Glucose-d1-3 is the deuterium labeled D-Glucose. D-Glucose, a monosaccharide, is an important carbohydrate and critical component of general metabolism and signaling pathways.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Glycine-1-13C | 20110-59-2 | AKOS015894426 | 99.4% | 76.06 g/mol | C13CH5NO2 | 25mg
Glycine-1-13C is the 13C-labeled Glycine Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors
Cayman Chemical VarenIclIn-d4 500ug
An internal standard for the quantification of varenicline by GC- or LC-MS
Medchemexpress LLC Glutaric acid-d4 | 19136-99-3 | MFCD00209727 | 99.46% | 136.14 | 100 MG
Glutaric acid-d4 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Gallic acid-d2 (3,4,5-Trihydroxybenzoic acid-d2) | 294660-92-7 | 172.13 | 5 MG
Gallic acid-d2 is the deuterium labeled Gallic acid. Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and a free radical scavenger that inhibits cyclooxygenase-2 (COX-2). Gallic acid exhibits various activities, including antimicrobial, antioxidant, anti-inflammatory, and anticancer activities.
- Can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
Cayman Chemical FenretInIde-d4 1mg
An internal standard for the quantification of fenretinide by GC- or LC-MS
Medchemexpress LLC (R)-Lansoprazole-d4 (dexlansoprazole-d4) | 138530-94-6 | 99.13% | 373.39 | 1 MG
(R)-Lansoprazole-d4 is a deuterium-labeled variant of (R)-Lansoprazole, also known as Dexlansoprazole-d4. (R)-Lansoprazole is the R enantiomer of Lansoprazole, an orally active proton pump inhibitor that effectively reduces stomach acid production. Additionally, it acts as a potent brain-penetrant neutral sphingomyelinase (N-SMase) inhibitor, which functions as an exosome inhibitor. This compound is suitable for research purposes only.
- Can be used as a tracer.
- Can serve as an internal standard for quantitative analysis via NMR, GC-MS, or LC-MS.
- Features stable heavy isotopes incorporated into drug molecules.
- Deuteration may influence pharmacokinetic and metabolic profiles of drugs.
Cayman Chemical UrsodeoxycholIc AcId-d4 500ug
An internal standard for the quantification of ursodeoxycholic acid by GC- or LC-MS
Medchemexpress LLC Phosphate dibasic-d1 (sodium) | 107632-22-4 | MFCD00190433 | 99.0% | 142.97 | DNa2O4P | 25mg
Phosphate dibasic-d2 (sodium) is the deuterium labeled Sodium phosphate dibasic[1]